Hemolytic-uremic syndrome caused by gemcitabine

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Gemcitabine-associated hemolytic-uremic syndrome.

BACKGROUND Gemcitabine has mild renal toxicity, but cases of gemcitabine-associated hemolytic-uremic syndrome (HUS) have been reported. METHODS A case is presented of a 45-year-old woman on prolonged gemcitabine treatment for ovarian cancer who developed HUS and recovered after drug discontinuation. A mini-review of the literature based on a MEDLINE search follows. RESULTS Including our own...

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Gemcitabine induced hemolytic uremic syndrome

BACKGROUND Gemcitabine is frequently used for the treatment of many cancers. Not infrequently it leads to development of hemolytic uremic syndrome, presenting with hemolytic anemia, acute kidney injury and occasionally peripheral edema, livedo reticularis and digital necrosis. CASE REPORT A 78 year old man with non-small cell lung cancer developed uremic syndrome following treatment with mult...

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Death caused by hemolytic - uremic syndrome . Case series

Hemolytic-uremic syndrome is defined by a combination between renal failure, microangiopathic hemolytic anemia and thrombocytopenia; it usually appears in young children, is preceded by gastrointestinal enteritis and may involve other organs as well. The purpose of this article is to present a series of four cases of lethal hemolytic uremic syndrome and discuss its legal medicine consequences. ...

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[Hemolytic uremic syndrome caused by enterohaemorrhagic Escherichia coli].

Hemolytic uremic syndrome (HUS) is characterized by microangiopathic hemolytic anemia, plaquetopenia and kidney damage. It is the leading cause of acute renal failure in pediatric age and the second for chronic renal failure. Shiga toxin-producing Escherichia coli (STEC) is the first etiologic agent of HUS being its main reservoir cattle and transmitted via contaminated food. At present, there ...

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Gemcitabine-associated Hemolytic-uremic Syndrome: a Case Report

Division of Nephrology, Department of Medicine, Department of Pathology*, Changhua Christian Hospital, Changhua, Taiwan Received: August, 2003 Revised: October, 2003 Accepted: January, 2004 Address reprint request to: Yao-Ko Wen, M.D., Division of Nephrology, Department of Medicine, Changhua Christian Hospital, 135 Nansiao St., Changhua 500, Taiwan Tel: (04) 7238595 ext 3991 Fax: 728923304 E-ma...

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ژورنال

عنوان ژورنال: Annals of Oncology

سال: 1998

ISSN: 0923-7534

DOI: 10.1023/a:1008467914836